What Is the Duration of BOTOX? Because BOTOX treatments are not permanent, they should be included in your health and beauty routine on a regular basis. The BOTOX protein’s skin-firming component fades over time, although benefits can last up to three months. This will differ depending on how strong the muscles in the treated area are. BOTOX is a fantastic alternative to plastic surgery because of its low cost and ease of application. Please ask Raleigh Plastic Surgery for more details. The website is raleighplasticsurgery.com, and our phone number is 919-872-2616.